Antifungal Drugs and Uses

Dr. Ram Bahadur Bohara
Dr. Ram Bdr Bohara

Antifungal Drugs and Uses । There are types of antifungal drugs : Agents which are used drugs which are used by mouth or by Capsule, tablet for the treatment of systemic fungal infections.

1. Fluconazole (Flucaz) 150 mg tablet

It is very commonly used for the treatment of systemic fungal infection and moniliasis (candida-a mould). It usual dose is 150 mg Capsule once a day for 2 weeks.

In light skin infection fluconazole is advised to be taken once a week because it stays longer in body.

Eye drops are used for fungal infection of cornea. It may case upset bowel, pain in abdomen and headache. In some cases liver may be affected.

It is not given in pregnancy and during Breast feeding. When phenytoin, cisapride and antibiotic are taking with it some changes in doses are required.

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2. Griseofulvin (Gidifulvin) 250mg tablet

There antifungal drugs antibiotic used by mouth for the treatment of skin fungal disease such as tinea corpris (ring worm),tinea capitis and fungal diseases affecting toes and nails.

Usual dose is 125, 250 mg twice a day with food. Usual duration of treatment in 3 weeks for skin infections and 12 months for toes/nails infection.

It is well tolerated but alcohol should not be taken during medication. It may cause headache and bowel upset.

3. Itraconazole Capsule (Cantrol)

It has broader activity than fluconazole and effective against Aspergillums fungal infections. Its usual dose is 200mg once a day.

It may cause stomach upset, dizziness, fall in blood potassium, unsteadiness and loss of sexual desire. It is also not given in pregnancy and during Brest feeding.

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4. Ketoconazole

It has been used for quite some time now but has a number of adverse effects such as loss of appetite, vomiting, loss of hair, headache & numbness, hormonal disturbance (decreased male hormones) such as enlargement of male breast, loss of desire and fall in spasm-counts. In females it may cause irregular menstrual cycle.

It may cause mild degree of liver damage also. The most dreaded problem with Ketocanazole is occuence of heart rhythm disturbance with concurrent use of cisapride, terfenadine.

It raises levels of other drugs such as rifampicin, phenytoin and antibiotic drugs in the blood. Because of these reasons and availability of safer drugs Ketocanazole is less preferred nowadays.

* Dr. Ram Bahadur Bohara is the Chairman of the of Nepal Alternative Medical Development Council and Advisor of Science Infotech. 

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